Publications

l-Arginine Treatment Alters the Kinetics of Nitric Oxide and Superoxide Release and Reduces Ischemia/Reperfusion Injury in Skeletal Muscle.
I. Huk, J. Nanobashvili, C. Neumayer, A. Punz, M. Mueller, K. Afkhampour, M. Mittlboeck, U. Losert, P.Polterauer, E.Roth, S. Patton, and T. Malinski
Originally published 15 Jul 1997| DOI: 10.1161/01.CIR.96.2.667 |Circulation. 1997;96:667–675

Nitric oxide is the mediator of both endothelium-dependent relaxation and hyperpolarization of the rabbit carotid artery.
R A Cohen 1, F Plane, S Najibi, I Huk, T Malinski, C J Garland
Originally published 15 April 1997| DOI: 10.1073/pnas.94.8.4193 |Proceedings of the National Academy of Sciences of the United States of America (PNAS). 1997 94 (8) 4193-4198 |PMID: 9108128|PMCID: PMC20600

Bioflavonoid quercetin scavenges superoxide and increases nitric oxide concentration in ischaemia-reperfusion injury: an experimental study.
I Huk, V Brovkovych, J Nanobash Vili, G Weigel, C Neumayer, L Partyka, S Patton, T Malinski
Originally published 8 August 1998| DOI: 10.1046/j.1365-2168.1998.00787.x | British Journal of Surgery. Volume 85, Issue 8, August 1998, Pages 1080–1085 | PMID: 9718001

S-Nitroso Human Serum Albumin Treatment Reduces Ischemia/Reperfusion Injury in Skeletal Muscle via Nitric Oxide Release.
S. Hallström, H. Gasser, C. Neumayer, A. Fügl, J. Nanobashvili, A. Jakubowski, I. Huk, Günther Schlag, and Tadeusz Malinski
Originally published 28 May 2002 | doi: 10.1161/01.CIR.0000018745.11739.9B | Circulation. 2002; 105:3032–3038

Endovascular Stent Grafting Versus Open Surgical Operation in Patients With Infrarenal Aortic Aneurysms. A Propensity Score–Adjusted Analysis.
H. Teufelsbauer, A. M. Prusa, K. Wolff, P. Polterauer, J. Nanobashvili, M. Prager, T. Hölzenbein, S. Thurnher, J. Lammer, M. Schemper, G. Kretschmer, and I. Huk
Originally published 29 Jul 2002 | doi: 10.1161/01.CIR.0000028603.73287.7D | Circulation. 2002; 106:782–787

Interleukin-33 induces expression of adhesion molecules and inflammatory activation in human endothelial cells and in human atherosclerotic plaques.
Demyanets S, Konya V, Kastl SP, Kaun C, Rauscher S, Niessner A, Pentz R, Pfaffenberger S, Rychli K, Lemberger CE, de Martin R, Heinemann A, Huk I, Gröger M, Maurer G, Huber K, Wojta J.
Originally published 7 Jul 2011| DOI: 10.1161/ATVBAHA.111.231431 |Arteriosclerosis, Thrombosis, and Vascular Biology. 2011;31:2080–2089

Oncostatin M- enhanced vascular endothelial growth factor expression in human vascular smooth muscle cells involves PI3K-, p38 MAPK-, Erk1/2- and STAT1/STAT3-dependent pathways and is attenuated by interferon-y.
Originally published 21 December 2010 | DOI: 10.1007/s00395-010-0141-0 | Basic Research in Cardiology 2011;106(2):217-31. | PMID: 21174212 | IF = 6.4

Simvastatin decreases free radicals formation in the human abdominal aortic aneurysm wall via NF-KB.
Piechota-Polanczyk A, Goraca A, Demyanets S, Mittlboeck M, Domenig C, Neumayer C, Wojta J, Nanobachvili J, Huk I, Klinger M.
Originally published 13 June, 2012| DOI: 10.1016/j.ejvs.2012.04.020 | European Journal of Vascular and Endovascular Surgery. 2012 Aug; 44(2):133-7 | PMID: 22694979 | IF = 5.3

Decreased tissue ´levels of cyclophilin A, a cyclosporine a target and phospho-ERK1/2 in simvastatin patients with abdominal aortic aneurysm.
Eur J Vasc Endovasc Surg. 2013;45(6):682-8. doi: 10.1016/j.ejvs.2013.02.015. IF = 5.3 Piechota-Polanczyk A, Demyanets S, Nykonenko 0, Huk I, Mittlboeck M, Domenig CM, Neumayer C, Wojta J, Nanobachvili J, Klinger M.
Originally published 3 April 2013 | DOI: 10.1016/j.ejvs.2013.02.015 | European Journal of Vascular and Endovascular Surgery. 2013 Jun;45(6):682-8 | PMID: 23558220 | IF = 5.3

Interleukin-33 induces urokinase in human endothelial cells–possible impact on angiogenesis. 
Stojkovic S, Kaun C, Heinz M, Krychtiuk KA, Rauscher S, Lemberger CE, de Martin R, Gröger M, Petzelbauer P, Huk I, Huber K, Wojta J, Demyanets S.
Originally published 7 April 2014| DOI: 10.1160/TH15-12-0917 | Journal of Thrombosis and Haemostasis 2014;12(6):948- 57 | PMID: 24702774 | IF = 4.1

The Influence of Simvastatin on NGAL, Matrix Metalloproteinases and Their Tissue Inhibitors in Human Intřaluminal Thrombus and Abdominal Aortic Aneurysm Tissue.
Piechota-Polanczyk A, Demyanets S, Mittlboeck M, Hofmann M, Domenig CM, Neumayer C, Wojta J, Klinger M, Nanobachvili J, Huk I.
Originally published March 22, 2015 | DOI: 10.1016/j.ejvs.2015.02.011 | European Journal of Vascular and Endovascular Surgery. 2015 May;49(5):549-55| PMID: 25800096| IF = 5.3

The Abdominal Aortic Aneurysm and Intraluminal Thrombus: Current Concepts of Development and Treatment.
Piechota-Polanczyk A, Jozkowicz A, Nowak W, Eilenberg W, Neumayer C, Malinski T, Huk I, Brostjan C.
Originally published 26 May 2015 | DOI: 10.3389/fcvm.2015.00019 | Frontiers in Cardiovascular Medicine. 2015 May 26;2:19| PMID: 26664891| PMCID: PMC4671358

Neutrophil Gelatinase-Associated Lipocalin (NGAL) is associated with symptomatic carotid atherosclerosis and drives pro-inflammatory state in vitro.
Eilenberg W, Stojkovic S, Piechota-Polanczyk A, Kaun C, Rauscher S, Gröger M, Klinger M, Wojta J, Neumayer C, Huk I, Demyanets S.
Originally published 29 February 2016 |DOI: 10.1016/j.ejvs.2016.01.009 | European Journal of Vascular and Endovascular Surgery. 2016 May;51(5):623-31 | PMID: 26947538 | IF = 5.3

Interleukin-33 stimulates GM-CSF and M-CSF production by human endothelial cells.
Montanari E, Stojkovic S, Kaun C, Lemberger CE, de Martin R, Rauscher S, Gröger M, Maurer G, Neumayer C, Huk I, Huber K, Demyanets S, Wojta J.
Originally published 12 May 2016 |DOI: 10.1160/TH15-12-0917 | Thrombosis and Haemostasis. 2016 Aug 1;116(2):317-27 | PMID: 27173404 | IF = 4.3

Tissue factor is induced by interleukin-33 in human endothelial cells: a new link between coagulation and inflammation.
Stojkovic S, Kaun C, Basilio J, Rauscher S, Hell L, Krychtiuk KA, Bonstingl C, de Martin R, Gröger M, Ay C, Holnthoner W, Eppel W, Neumayer C, Huk I, Huber K, Demyanets S, Wojta J.
Originally published 4 May 2016 |DOI: 10.1038/srep25171 | Scientific Reports. 2016 May 4;6:25171| PMID: 27142573 | PMCID: PMC4855148  

Age intrinsic loss of telomere protection via TRF1 reduction in endothelial cells.
Hohensinner PJ, Kaun C, Buchberger E, Ebenbauer B, Demyanets S, Huk I, Eppel W, Maurer G, Huber K, Wojta J.
Originally published 1 December 2015 |DOI: 10.1016/j.bbamcr.2015.11.034| Biochimica et Biophysica Acta. 2016 Feb;1863(2):360-7 | PMID: 26658719

IL-33 stimulates the release of procoagulant microvesicles from human monocytes and differentially increases tissue factor in human monocyte subsets.
Stojkovic S, Thulin Å, Hell L, Thaler B, Rauscher S, Baumgartner J, Gröger M, Ay C, Demyanets S, Neumayer C, Huk I, Spittler A, Huber K, Wojta J, Siegbahn A, Åberg M.
Originally published 11 May 2017 |DOI: 10.1160/TH16-10-0784 | Thrombosis and Haemostasis. 2017 Jun 28;117(7):1379-1390 | PMID: 28492698 | IF = 4.1

NGAL and MMP-9/NGAL as biomarkers of plaque vulnerability and targets of -statins in patients with carotid atherosclerosis.
Eilenberg W, Stojkovic S, Kaider A, Kozakowski N, Domenig CM, Burghuber C, Nanobachvili J, Huber K, Klinger M, Neumayer C, Huk I, Wojta J, Demyanets S.
Originally published 26 June 2017|DOI: 10.1515/cclm-2017-0156 | Clinical Chemistry and Laboratory Medicine. 2017 Nov 27;56(1):147-156| PMID: 28672747

Neutrophil gelatinase associated lipocalin (NGAL) is elevated in type 2 diabetics with carotid artery stenosis and reduced under metformin treatment.
Eilenberg W, Stojkovic S, Piechota-Polanczyk A, Kaider A, Kozakowski N, Weninger WJ, Nanobachvili J, Wojta J, Huk I, Demyanets S, Neumayer C.
Originally published 8 August 2017 |DOI: 10.1186/s12933-017-0579-6 | Cardiovascular Diabetology. 2017 Aug 8;16(1):98 | PMID: 28789657 | PMCID: PMC5549375 | IF = 5.2

Computational fluid dynamic accuracy in mimicking changes in blood hemodynamics in patients with acute type III aortic dissection treated with TEVAR.
Polanczyk, A., Piechota-Polanczyk, A., Domenig, C., ..Huk, I., Neumayer, C.
Originally published 7 August 2018 |DOI: 10.3390/app8081309| Applied Sciences (Switzerland), 2018, 8(8), 1309

Artificial circulatory model for analysis of human and artificial vessels. Applied Sciences.
Polanczyk, A., Klinger, M., Nanobachvili, J., Huk, I., Neumayer, C.
Originally published 22 June 2018 |DOI: 10.3390/app8071017 | Applied Sciences (Switzerland). 2018, 8(7), 1017

Simvastatin Treatment Upregulates HO-1 in Patients with Abdominal Aortic Aneurysm but Independently of Nrf2.
Piechota-Polanczyk A, Kopacz A, Kloska D, Zagrapan B, Neumayer C, Grochot-Przeczek A, Huk I, Brostjan C, Dulak J, Jozkowicz A.
Originally published 20 March 2018 |DOI: 10.1155/2018/2028936 | Oxidative Medicine and Cellular Longevity. 2018 Mar 20; 2018:2028936 | PMID: 29743974 | PMCID: PMC5883937

Lower levels of Caveolin-1 and higher levels of endothelial nitric oxide synthase are observed in abdominal aortic aneurysm patients treated with simvastatin.
Kowalska K, Habrowska-Górczyńska DE, Neumayer C, Bolliger M, Domenig C, Piastowska-Ciesielska AW, Huk I, Piechota-Polanczyk A.
Originally published 15 March 2018 |DOI: 10.18388/abp.2017_2305 | Acta Biochimica Polonica. 2018; 65(1):111-118| PMID: 29549671

Neutrophil Gelatinase Associated Lipocalin (NGAL) for Identification of Unstable Plaques in Patients with Asymptomatic Carotid Stenosis.
Eilenberg W, Stojkovic S, Kaider A, Piechota-Polanczyk A, Nanobachvili J, Domenig CM, Wojta J, Huk I, Demyanets S, Neumayer C.
Originally published 1 June 2019 |DOI:  10.1016/j.ejvs.2018.12.029 | European Journal of Vascular and Endovascular Surgery. 2019 Jun;57(6):768-777 | PMID: 31164272 | IF = 5.3

Diagnostic and Prognostic Score for Abdominal Aortic Aneurysms Based on D-Dimer and a Comprehensive Analysis of Myeloid Cell Parameters.
Zagrapan B, Eilenberg W, Prausmueller S, Nawrozi P, Muench K, Hetzer S, Elleder V, Rajic R, Juster F, Martelanz L, Hayden H, Klopf J, Inan C, Teubenbacher P, Weigl MP, Kirchweger P, Beitzke D, Jilma B, Wojta J, Bailey MA, Scott DJA, Huk I, Neumayer C, Brostjan C. A Novel
Originally published 1 March 2019 |DOI: 10.1055/s-0039-1679939 | Thrombosis and Haemostasis. 2019 May;119(5):807-820 | PMID: 30822810 | IF = 4.1

Differential expression of Plg-RKT and its effects on migration of proinflammatory monocyte and macrophage subsets.
Thaler B, Baik N, Hohensinner PJ, Baumgartner J, Panzenböck A, Stojkovic S, Demyanets S, Huk I, Rega-Kaun G, Kaun C, Prager M, Fischer MB, Huber K, Speidl WS, Parmer RJ, Miles LA, Wojta J.
Originally published 20 Jun 2019 |DOI: 10.1182/blood.2018850420 | Blood. 2019 Aug 8;134(6):561-567 | PMID: 31221672 | IF = 17.7

Interaction off Adipose-Derived Stromal Cells with Breast Cancer Cell Lines.
Teufelsbauer M., Rath B, Moser D, Hasliok W, Huk I, Hamilton G.
Originally published August 2019 |DOI: 10.1097/PRS.0000000000005839 | Plastic and Reconstructive Surgery. 2019 Aug; 144 (2): 207e-217e | PIMD:31348343

Biliverdin reductase deficiency triggers an endothelial-to-mesenchymal transition in human endothelial cells.
Klóska D, Kopacz A, Piechota-Polańczyk A, Neumayer C, Huk I, Dulak J, Józkowicz A, Grochot-Przęczek A. Arch
Originally published 5 November 2019 |DOI: 10.1016/j.abb.2019.108182 | Archives of Biochemistry and Biophysics. 2019 Dec 15;678:108182 | PMID: 31704097

Insight into the expression of toll-like receptors 2 and 4 in patients with abdominal aortic aneurysm.
Jabłońska A, Neumayer C, Bolliger M, Burghuber C, Klinger M, Demyanets S, Nanobachvili J, Huk I.
Originally published 7 March 2020 |DOI: 10.1007/s11033-020-05366-x | Molecular Biology Reports. 2020 Apr;47(4):2685-2692 | PMID: 32146682

Effects of metformin on adipose-derived stromal cell (ADSC)-Breast cancer cell lines interaction.
Teufelsbauer M, Rath B, Plangger A, Staud C, Nanobashvili J, Huk I, Neumayer Ch, Hamilton G.
Originally published 31 August 2020 |DOI: 10.1016/j.lfs.2020.118371 | Life Sciences. 2020 Nov. 15; 261:118371| PMID: 32882267

TLR2 2029C/T and TLR3 1377C/T and -7C/A Polymorphisms Are Associated with the Occurrence of Abdominal Aortic Aneurysm.
Jabłońska A, Zagrapan B, Neumayer C, Klinger M, Eilenberg W, Nanobachvili J, Paradowska E, Brostjan C, Huk I.
Originally published 13 April 2020 |DOI: 10.4049/jimmunol. 1901014| The Journal of Immunology. 2020 Jun 1;204(11):2900-2909| PMID: 32882267

Polymorphisms in the IL-6 and TNF-a gene are associated with an increased risk of abdominal aortic aneurysm.
Jabłońska A, Zagrapan B, Neumayer C, Eilenberg W, Scheuba A, Brostjan C, Demyanets S, Klinger M, Nanobachvili J, Huk I.
Originally published 6 January 2021 |DOI: 10.1016/j.ijcard.2020.12.051 | International Journal of Cardiology. 2021 Jan 6:S0167-5273(20)34299-6| PMID: 33359288

Inverse probability of treatment analysis of open vs endovascular repair in ruptured infrarenal aortic aneurysm – Cohort study.
Eilenberg W, Schwarz M, Schoder M, Klinger M, Kinstner C, Nanobachvili J, Huk I, Neumayer C, Heinze G, Domenig CM.
Originally published 15 June 2020 | DOI: 10.1016/j.ijsu.2020.05.090 | International Journal of Surgery. 2020 Aug;80:218-224| PMID: 32553807

Complement Factor C5a Is Increased in Blood of Patients with Abdominal Aortic Aneurysm and Has Prognostic Potential for Aneurysm Growth.
Zagrapan B, Eilenberg W, Scheuba A, Klopf J, Brandau A, Story J, Dosch K, Hayden H, Domenig CM, Fuchs L, Schernthaner R, Ristl R, Huk I, Neumayer C, Brostjan C. J.
Originally published 17 December 2020 |DOI: 10.1007/s12265-020-10086-5 | Journal of Cardiovascular Translational Research. 2021 Aug;14(4):761-769 | PMID: 33332020 | PMCID: PMC8397625

Insight into the expression of toll-like receptors 2 and 4 in patients with abdominal aortic aneurysm.
Jabłońska A, Neumayer C, Bolliger M, Burghuber C, Klinger M, Demyanets S, Nanobachvili J, Huk I.
Originally published 7 March 2020 |DOI: 10.1007/s11033-020-05366-x | Molecular Biology Reports. 2020;47(4):2685-2692| PMID: 32146682

Polymorphism in the IL-6 and TNF-a gene are associated with an increased risk of abdominal aortic aneurysm.
Jabłońska A, Zagrapan B, Neumayer C, Eilenberg W, Scheuba A, Brostjan C, Demyanets S, Klinger M, Nanobachvili J, Huk I
Originally published 6 January 2021 |DOI: 10.1016/j.ijcard.2020.12.05.1| International Journal of Cardiology. 2021 Jan 6:S0167-5273(20)34299-6| PMID: 33359288

Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms.
Eilenberg W, Zagrapan B, Bleichert S, Ibrahim N, Knöbl V, Brandau A. et al. Huk I, Christoph Neumayer C, Brostjan.
Originally published 9 February 2021 |DOI: 10.1016/j.trsl.2021.02.003| Translation Research. 2021 Jul;233:32-46| PMID: 33571683

Abdominal aortic aneurysm and virus infection: A potential causative role for cytomegalovirus infection?
Agnieszka Jabłońska, Branislav Zagrapan, Edyta Paradowska, Christoph Neumayer, Wolf Eilenberg, Christine Brostjan, Markus Klinger, Josif Nanobachvili, Ihor Huk.
Originally published 3 May 2021 |DOI: 10.1002/jmv.26901 |Journal of Medical Virology. 2021 Aug;93(8):5017-5024| PMID: 33629381